The first important step analyzing mammographically detected microcalcifications is determination of the anatomic cavity within which the calcifications have been formed and are localized. If we can determine that the calcifications are not localized within the major lactiferous ducts and the TDLUs, then we talk about miscellaneous calcifications that do not represent a malignant process. This lecture details the pathophysiology of the evolution of the majority of miscellaneous calcifications and provides a detailed description of their histopathologic-mammographic features.